Bio
I am Molecular Biologist PhD Student at the Buenos
Aires University (UBA), Argentina working in the Biomedicine
Institute of Buenos Aires. I am highly interested in
understanding the genetic regulatory networks and molecular
signal pathways that drive kidney cancer.
Research
The main aim of my study is to understand the mechanisms behind tumorigenesis and improve treatments in kidney cancer. I focus on the RSUME oncogene’s involvement in the development of Von Hippel Lindau tumors. I analyze genomic and transcriptomic datasets and perform wet lab experiments to support my findings.
Education
| University of Buenos Aires, Argentina | 2019 - Present |
| Ph.D. in Kidney Cancer Biology | |
| Cold Spring Harbor Laboratory, New York | July 2023 |
| Statistical Analysis of Genome Scale Data | |
| University of Buenos Aires, Argentina | 2012 - 2019 |
| Licenciatura (seven-year degree equivalent to Bachelor and Master combined) in Biological Sciences |
Technical Skills
| Experimental | Bioinformatic |
| Cell Culture | R and Bioconductor |
| Immunofluorescent Staining | Python |
| Angiogenesis and Tumorigenesis assays | FIJI |
| Confocal and Widefield Microscopy | Microarray analysis |
| RNA Isolation and cDNA Synthesis | RNA-seq analysis |
| PCR and Western blot |
Teaching
| University of Jose C. Paz, Argentina | 2021-present |
| Teaching as chief of practical applications, University of Jose C. Paz. Courses taught: Biostatistics and Demography, Microbiology and Parasitology. | |
| University of Buenos Aires, Argentina | 2019-2021 |
| Teaching assistant, University of Buenos Aires. Courses taught: Introduction to Molecular Bioinformatics, Biological Chemistry, Genetics I. |
Published Works
Expression of RSUME is Associated With Poor Prognosis in Clear Cell Renal Carcinoma: Involvement of ROS Related Metabolism | David Gonilski Pacin, Nicolás Ciancio del Giudice, Belén Elguero, Eduardo Arzt. Clinical Genitourinary Cancer (2023)
Impact of RSUME Actions on Biomolecular Modifications in Physio-Pathological Processes | Mariana Fuertes, Belén Elguero, David Gonilski-Pacin, …, Eduardo Arzt “Impact of RSUME Actions on Biomolecular Modifications in Physio-Pathological Processes”. Review article in Frontiers in Endocrinology (2022).
von Hippel-Lindau mutants in renal cell carcinoma are regulated by increased expression of RSUME | Lucas Tedesco, Belen Elguero, David Gonilski Pacin, …, Eduardo Arzt. “von Hippel-Lindau mutants in renal cell carcinoma are regulated by increased expression of RSUME”. Cell Death & Disease (2019)
Mass Spectrometry-Based Metabolic Fingerprinting Contributes to Unveil the Role of RSUME in Renal Cell Carcinoma Cell Metabolism | Manuela Martinefski, Belen Elguero, María Knott, David Gonilski Pacin, …, Eduardo Arzt, María Eugenia Monge. Journal of Proteome Research (2021).
Interests and Hobbies
You can usually find me rowing or playing soccer! I
also love singing and playing the guitar.